shRNA technology: Investigating Ras-dependent cancer
نویسندگان
چکیده
منابع مشابه
The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways
Ras and Rac are membrane-associated GTPases that function as molecular switches activating intracellular mitogen-activated protein kinase (MAPK) cascades and other effector pathways in response to extracellular signals [1]. Activation of Ras and Rac into their GTP-bound conformations is directly controlled by specific guanine-nucleotide exchange factors (GEFs), which catalyze GDP release. Sever...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2009
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.8.19.9681